Welcome to the Schubot Lab!

We use an integrated approach to study molecular mechanisms underlying signal transduction in bacteria. We are particularly interested in non-canonical systems that modulate virulence gene expression in the opportunistic pathogen Pseudomonas aeruginosa. Examples include the ExsA-ExsC-ExsD-ExsE signaling cascade, which uses a partner-switching mechanism to regulate expression of the type secretion system in response to host-cell contact. Using the GacS/GacA system as a model we are also deeply interested uncovering the mechanisms underlying crosstalk between signaling histidine kinases in multikinase networks.